Does the Brain Make the Heart Beat?
In short: Each normal heartbeat is started by pacemaker cells in the heart's own sinoatrial node, while the brain speeds that rhythm up or slows it down through sympathetic and vagal nerve activity.
A 2:00 short film in the series “Photon and Brain”, narrated by intellect_voice_01.
Sources used in this film: PubMed Central (PMC), U.S. National Library of Medicine, National Institutes of Health, “Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis”; Johns Hopkins Medicine, “Anatomy and Function of the Heart's Electrical System”; Proceedings of the National Academy of Sciences (PNAS), hosted on PubMed Central (US National Library of Medicine, NIH), “Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes”; PubMed Central (National Center for Biotechnology Information, US National Library of Medicine), “Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current”; PubMed Central (PMC), U.S. National Library of Medicine, “Autonomic and endocrine control of cardiovascular function”; Frontiers in Physiology (Frontiers Media), “Frontiers | Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans”; PubMed Central (PMC), US National Library of Medicine / National Center for Biotechnology Information, “Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training”; PubMed Central (PMC), U.S. National Library of Medicine, National Institutes of Health; review article on the history of the isolated heart perfusion model, “History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology”.
Sources used in this film
- PubMed Central (PMC), U.S. National Library of Medicine, National Institutes of Health — Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis · View →
- Johns Hopkins Medicine — Anatomy and Function of the Heart's Electrical System · View →
- Proceedings of the National Academy of Sciences (PNAS), hosted on PubMed Central (US National Library of Medicine, NIH) — Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes · View →
- PubMed Central (National Center for Biotechnology Information, US National Library of Medicine) — Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current · View →
- PubMed Central (PMC), U.S. National Library of Medicine — Autonomic and endocrine control of cardiovascular function · View →
- Frontiers in Physiology (Frontiers Media) — Frontiers | Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans · View →
- PubMed Central (PMC), US National Library of Medicine / National Center for Biotechnology Information — Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training · View →
- PubMed Central (PMC), U.S. National Library of Medicine, National Institutes of Health; review article on the history of the isolated heart perfusion model — History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology · View →
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Sources
- Summary by Intellect · source: PubMed Central (PMC), U.S. National Library of Medicine, National Institutes of Health: Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
- Also: Anatomy and Function of the Heart's Electrical System
- Also: Proceedings of the National Academy of Sciences (PNAS), hosted on PubMed Central (US National Library of Medicine, NIH): Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes
- Also: PubMed Central (National Center for Biotechnology Information, US National Library of Medicine): Pacemaker Activity of the Human Sinoatrial Node: An Update on the Effects of Mutations in HCN4 on the Hyperpolarization-Activated Current
- Also: PubMed Central (PMC), U.S. National Library of Medicine: Autonomic and endocrine control of cardiovascular function
- Also: Frontiers in Physiology (Frontiers Media): Frontiers | Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans
- Also: PubMed Central (PMC), US National Library of Medicine / National Center for Biotechnology Information: Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training
- Also: PubMed Central (PMC), U.S. National Library of Medicine, National Institutes of Health; review article on the history of: History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology
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