Vaccine protection against the Delta variant appeared to decline months after vaccination
In short: Researchers analyzing Israeli national health records compared Covid-19 infection rates among people fully vaccinated with BNT162b2 at different points earlier in 2021. Across three age groups, those vaccinated soonest after becoming eligible had notably higher infection rates in July 2021 than people vaccinated about two months later, suggesting that protection had weakened over time.
The team used a Poisson regression model, adjusting for age and other factors, to compare infection and severe-disease rates across vaccination-timing groups using national data from July 11-31, 2021. Severe disease followed a similar pattern in the two older age groups, though rate ratios could not be calculated for the youngest group because of small case numbers.
Why it matters: the findings point to fading vaccine-induced protection against the Delta variant within months, though as an observational comparison it cannot rule out other explanations for the pattern.
Why it matters: The results suggest vaccine protection against Delta may fade within months, which is relevant to understanding outbreak resurgences.
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Sources
- Summary by Intellect · source: Research: Goldberg et al. (2021). Waning Immunity after the BNT162b2 Vaccine in Israel. New England Journal of Medicine.
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