When a simple flap of tissue becomes a life-threatening airway emergency

Acute Epiglottitis - signs and symptoms, causes, pathophysiology, treatment · 7:25 · Video: Armando Hasudungan · Watch at the source

In short: The epiglottis is a small flap that protects your windpipe while you swallow. But when it becomes inflamed, it can rapidly swell to block your breathing entirely. This medical emergency requires immediate intervention because the transition from a sore throat to total airway obstruction can happen in minutes.

Acute epiglottitis is characterized by the rapid inflammation of the epiglottis, the structure responsible for covering the windpipe during swallowing. When this tissue swells, it can physically obstruct the airway, making breathing extremely difficult. In young children, who have smaller airways, these symptoms often appear without warning and escalate quickly. Adults may experience a slightly slower progression, sometimes taking several days for full symptoms to develop.

The primary driver of this condition is bacterial infection. Haemophilus influenzae type b (Hib) is the most common cause in children, spreading through coughing, sneezing, or touching contaminated surfaces. In adults, however, non-Hib sources like Streptococcus pneumoniae and Staphylococcus are more frequent. Other triggers include viral infections—such as varicella-zoster or herpes simplex—which can weaken the immune system, fungal infections like Candida, or physical trauma from hot liquids, chemical burns, or smoking substances like crack cocaine.

Clinical signs often include a high-pitched, rasping sound during inhalation, severe sore throat, and involuntary drooling due to difficulty swallowing (dysphagia). A hallmark sign in children is the 'tripod' position: sitting upright, leaning forward with the neck pushed out to maximize air intake. Because of the risk of total obstruction, immediate hospital treatment is required. This may involve oxygen therapy, intravenous antibiotics, or emergency procedures like a tracheostomy—creating an opening in the neck—to secure the airway.

Diagnosis often involves urgent imaging such as X-rays or CT scans, and laryngoscopy to visualize the throat with a camera. While most patients make a full recovery with proper hospital care, the rapid onset of symptoms makes it a critical emergency that requires swift identification to prevent asphyxiation.

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