How an immunosuppressant targets mitochondrial enzymes to treat chronic inflammation
In short: Explore the pharmacology of Leflunomide, a medication used for conditions like rheumatoid arthritis and multiple sclerosis. This video explains how it transforms within the body to regulate the immune system.
Leflunomide functions as a prodrug, meaning it is inactive until it undergoes rapid and nearly complete metabolism after being taken orally. It converts into its active form, known as A77 1726 or teriflunomide.
While the exact mechanism of action is not fully understood, research suggests that the drug primarily works by inhibiting dihydroorotate dehydrogenase, a specific enzyme found in mitochondria. This process helps manage symptoms of rheumatoid arthritis, psoriatic arthritis, and multiple sclerosis.
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Sources
- Summary by Intellect · source: Leflunomide (DMARD) pharmacology - mechanism of action, adverse effects and cholestyramine
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