The liver is a chemical factory with a dual-source plumbing system

Liver Anatomy and Blood Supply · 8:12 · Video: Armando Hasudungan · Watch at the source

In short: Most organs rely on a single circulatory path, but the liver operates on a unique double-entry system. It simultaneously processes oxygen-rich blood and nutrient-heavy blood from your digestive tract, allowing it to act as the body's primary refinery for everything from glucose to toxins.

The liver is a cone-shaped, dark reddish-brown organ located in the upper right portion of the abdominal cavity, situated beneath the diaphragm and atop the stomach and right kidney. Weighing approximately 3 pounds, it is massive enough to hold about one pint, or 13%, of the body's total blood supply at any given moment. Its internal architecture is highly organized, consisting of two main lobes divided into 8 segments, which are further subdivided into 1,000 small lobules.

What makes the liver's vascular system remarkable is its dual blood supply. It receives oxygenated blood via the hepatic artery and nutrient-rich blood from the hepatic portal vein. This second source is critical because all blood leaving the stomach and intestines must pass through the liver first. This allows the organ to intercept and process nutrients, metabolize drugs into non-toxic forms, and balance chemical levels before the blood reaches the rest of the body.

The liver performs over 500 vital functions. It acts as a storage unit for iron and converts excess glucose into glycogen for later use. It also manages protein metabolism by converting poisonous ammonia into urea, which is then excreted as urine. Furthermore, it produces bile to break down fats and carries away waste, while simultaneously creating blood plasma proteins and regulating clotting factors. When the liver successfully clears bilirubin from red blood cells, it prevents the skin and eyes from turning yellow; if this process fails, waste by-products can accumulate in the body.

The waste products of these processes are handled through two distinct exit routes. By-products that enter the bile are sent to the gallbladder and the duodenum, eventually leaving the body as feces. Blood-filtered by-products are sent to the kidneys to be excreted as urine. This sophisticated filtration ensures that the body's internal chemistry remains stable and free of toxins.

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