Longer intervals between vaccine doses may improve overall protection
In short: Researchers analyzing four clinical trials found that the timing between doses of the ChAdOx1 nCoV-19 vaccine significantly impacts its effectiveness. While a single dose provided substantial protection, participants who received their second dose after a longer interval of at least 12 weeks showed higher vaccine efficacy compared to those who received it in less than 6 weeks.
This pooled analysis of 24,422 participants explored how the timing of booster doses affects immunity. The study found that extending the interval between the first and second doses improved efficacy and antibody responses.
The researchers used data from four randomized trials, though the findings regarding efficacy and antibody levels were based on exploratory analyses.
Why it matters: The timing of vaccine doses can influence the strength of the immune response.
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