NAD+ precursor supplement boosted muscle insulin sensitivity in prediabetic women
In short: Researchers gave the NAD+ precursor nicotinamide mononucleotide to overweight or obese postmenopausal women with prediabetes and found it improved how their muscles responded to insulin. The supplement also increased expression of a growth factor called platelet-derived growth factor b, though the team could not detect any change in the women's actual NAD+ levels.
NAD+ production declines with age, and animal studies suggest restoring it can ease age-related disease, though evidence in people has been limited. Testing an NAD+ precursor directly in older, prediabetic women supports the idea that NAD+ supplementation could have therapeutic potential in humans.
The main limitation: the researchers could not confirm that the supplement actually raised NAD+ content in the body, and it remains unclear how such precursors are handled in different tissues.
Why it matters: An NAD+ precursor supplement improved muscle's response to insulin in prediabetic women, hinting at metabolic benefits whose mechanism is still unclear.
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Sources
- Summary by Intellect · source: Research: Yoshino et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science.
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