Weekly semaglutide injections paired with behavioral therapy led to greater weight loss
In short: In a 68-week randomized trial of 611 adults, researchers found that adding weekly 2.4 mg subcutaneous semaglutund injections to intensive behavioral therapy and a low-calorie diet resulted in significantly more weight loss than a placebo. Participants receiving the medication saw an estimated mean body weight reduction of 16.0%, compared to a 5.7% reduction in the placebo group.
The study, a phase 3a trial conducted across 41 US sites, demonstrated that a much higher proportion of the semaglutide group achieved weight losses of 10% or 15% compared to those receiving only the placebo and therapy. However, gastrointestinal side effects were more common in the semaglutide group, leading some participants to discontinue treatment.
While these results show significant weight reduction, the researchers noted that further studies are required to determine how long these weight loss effects might last.
Why it matters: Semaglutide injections significantly enhance weight loss when paired with intensive lifestyle interventions, though side effects may impact treatment adherence.
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Sources
- Summary by Intellect · source: Research: Wadden et al. (2021). Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity. JAMA.
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