Intellect PlusClinical trials
42 cards. Each one is a 40-second story with a five-minute read behind it.
Camrelizumab plus chemotherapy extends survival in advanced squamous NSCLCA phase 3 trial of 389 patients with advanced squamous NSCLC found that camrelizumab plus chemotherapy significantly improved progression-free survival and overall survival compar…
Tislelizumab plus chemotherapy improved survival in advanced oesophageal cancerA global trial of 649 patients found that tislelizumab plus chemotherapy significantly extended overall survival compared to placebo plus chemotherapy for advanced oesophageal squ…
Adding a specific medication to hormone therapy extends life for some breast cancer patientsA study of 334 postmenopausal women with advanced breast cancer found that combining the drug ribociclib with letrozole significantly extended overall survival compared to using l…
A new blood thinner significantly lowers stroke risk in heart patientsA study of 5,599 patients with atrial fibrillation found that a novel medication, apixaban, was more effective than aspirin at preventing strokes. The researchers focused on indiv…
The psychological cost of public service in ZacatecasIn the heart of Mexico, a study of government workers reveals how leadership styles directly shape mental well-being. By analyzing psychosocial risks within municipal agencies, re…
Can a democratic office create a more democratic nation?The 'spillover thesis' suggests that the way we behave at work shapes how we behave as citizens. If you learn to vote, debate, and collaborate in your office, you might become a m…
Money is not a tool; it is a social relation.We often view money as a neutral invention to solve the clunkiness of bartering. However, Karl Marx argued that money is actually a necessary social form. It isn't an external con…
The legal maze of a plant that looks like a common houseplantSalvia divinorum is often described by politicians as being as dangerous as LSD, yet it remains legal in most countries. This discrepancy highlights a fascinating tension between …- The Soviet Blueprint: How a Soviet Epidemiologist Shaped China's Public HealthIn the 1950s, the newly formed People's Republic of China sought to build a modern nation from the ground up. Central to this transformation was a Soviet expert who helped bridge …
Navigating a complex path toward public health stabilityBangladesh balances a rigid constitutional framework with ambitious public health goals. While the nation has successfully eradicated diseases like leprosy, it faces modern challe…
How institutional autonomy protects science from populist political pressureWhen a public health crisis hits, do politicians listen to experts or their own instincts? In Argentina, the tension between populist leadership and scientific evidence reveals a …
The socialist architect who drafted the blueprint for British public ownershipSidney Webb didn't just advocate for socialism; he engineered its institutional framework. From co-founding the London School of Economics to drafting the core principles of the B…
Democracy is not just a conversation; it is a physical presenceWe often think of democracy as a series of debates and speeches. But sociologist Richard Sennett argues that the most fundamental democratic acts are nonverbal and physical. By si…
The Greek party that rose from the ashes of a military dictatorshipFounded in 1974 by Konstantinos Karamanlis, New Democracy emerged during Greece's transition from military rule to democracy. While its roots trace back to the early 20th-century …- The radical splinter group that refused to compromise on apartheidWhen the ruling National Party began making concessions to the world, a hardline faction broke away to preserve a purer vision of segregation. They didn't just want a seat at the …
- The failed experiment of liberalizing a dictatorship from the insideCan a dictator truly surrender power on his own terms? In 1973, Greek leader Georgios Papadopoulos attempted to dismantle his own military junta through a process called metapolit…
The invisible geometry that defines ownership and state powerA cadastre is more than a map; it is a fundamental tool of governance. By translating messy physical reality into legible, line-by-line data, states can tax, trade, and control la…
Philosophy is not just for interpreting the world, but for transforming itKarl Marx famously rejected the idea that thinkers should merely observe reality. Instead, he proposed a radical shift: philosophy must become a tool for practical change. Discove…
Why the 'Plan' is making a sophisticated comeback in modern statesAfter the collapse of the Soviet Gosplan in 1991, many assumed state-level economic planning was a relic of the past. Yet, a new era of 'indicative' planning is emerging. It isn't…
Why predicting a diagnosis is often more effective than modeling the disease itselfIn machine learning, we often face a choice: do we try to understand how data is created, or simply learn to tell it apart? While generative models attempt to map the entire biolo…
Is the internet destroying our ability to have a shared public debate?The public sphere is supposed to be a neutral ground where citizens meet as equals to debate common interests and hold power to account. But in a digital age, this space is fractu…- The peaceful transfer of power is a habit-forming democratic miracle.While it feels like a routine civic duty, the peaceful handover of leadership is actually a rare and delicate achievement. Scholars suggest that once a nation successfully navigat…
- The new playbook for autocracy is being written from withinUnlike the military coups of the Cold War, today's slide toward authoritarianism often happens under the guise of legitimacy. Modern autocrats are not seizing power from the outsi…
- Were the Spanish American territories colonies or merely overseas provinces?History often paints the Spanish Empire as a system of economic exploitation. However, legal records suggest a far more complex reality: a pluralistic model of integration where A…
Can algorithms sense a life-threatening allergy before a human can?In the high-stakes world of healthcare, seconds determine survival. While doctors rely on physical symptoms, a new frontier of predictive analytics is using wearable sensors to de…
Why some democracies choose to ban political parties entirelyIn a world defined by partisan friction, some nations operate without political parties at all. From the tiny islands of the Pacific to the halls of ancient Athens, non-partisan s…
Can a fake match percentage actually make people like each other?In a bold A/B test, OkCupid researchers used a placebo match score to manipulate user connections. The results revealed a startling psychological truth: when we are told we are a …
Democracy moves in waves, not just random ripples of changeDemocratization is rarely a linear path. Instead, it tends to occur in global clusters of time and space. From the 19th-century expansion of suffrage to the modern era of hybrid r…- The ethical cornerstone of human research is undergoing a digital transformationSince 1964, the Declaration of Helsinki has been the global gold standard for medical ethics. But as artificial intelligence and massive biobanks reshape science, the world’s most…
Why modern medical ethics were born from historical tragediesThe rules governing how humans can be used in medical research didn't appear out of thin air. They were forged in the wake of systemic abuse, creating a framework to balance scien…
The gatekeepers of human research: how IRBs protect our rightsBefore a single patient joins a clinical trial, an independent committee must sign off on the ethics. These Institutional Review Boards (IRBs) serve as a vital shield, balancing t…- Why the quality of the process matters more than the final voteMost democracies treat voting as the ultimate goal, but deliberative democracy argues that a vote without prior reasoned debate is hollow. This theory suggests that for a decision…
The hidden architecture of choice: why 'informed' consent is rarely simpleTrue consent requires more than a signature. It demands a delicate balance of three pillars: voluntariness, information, and capacity. While a patient might agree to a procedure, …- The high cost of closing the global vaccine gapWhile routine childhood vaccinations have averted 154 million deaths since 1974, progress is stalling. Despite massive global expansion, millions of children remain 'zero-dose'—co…
- Brain imaging abnormalities were frequently observed during aducanumab clinical trialsResearchers analyzing two phase 3 clinical trials found that 41.3% of patients receiving aducanumab experienced amyloid-related imaging abnormalities (ARIA). In a group of 1,029 p…
- Combination therapies show improved progression-free survival in advanced renal cell carcinomaA phase 3 trial of 1,069 patients with advanced renal cell carcinoma found that combining lenvatinib with either pembrolizumab or everolimus extended the time before the disease p…
Combination therapy improves survival outcomes in advanced renal-cell carcinomaIn a phase 3 randomized trial of 651 adults, researchers found that combining nivolumab and cabozantinib significantly extended progression-free survival compared to sunitinib for…
Weekly semaglutide injections led to greater weight loss than daily liraglutideA 68-week clinical trial of 338 adults with overweight or obesity found that weekly subcutaneous semaglutide injections resulted in significantly more weight loss than daily lirag…- New drug improves survival in patients with advanced triple-negative breast cancerA phase 3 clinical trial involving 468 patients found that sacituzumab govitecan significantly extended survival for those with metastatic triple-negative breast cancer who had al…
Conflicting results for aducanumab in two phase 3 trials for early Alzheimer'sResearchers conducting two phase 3 clinical trials found that the monoclonal antibody aducanumab showed different results for patients with early Alzheimer's disease. While the EM…
Adding temozolomide to radiotherapy improves survival in patients with glioblastomaA randomized trial of 573 patients with newly diagnosed glioblastoma found that combining radiotherapy with the drug temozolomide increased median survival to 14.6 months, compare…- A multi-drug chemotherapy regimen extends life for patients with metastatic pancreatic cancerResearchers who conducted a clinical trial of 342 patients found that a four-drug chemotherapy combination, known as FOLFIRINOX, significantly extended survival compared to the st…