Pasteurized gut bacteria supplementation may improve insulin sensitivity and cholesterol levels
In short: Researchers conducting a pilot study of overweight and obese volunteers found that daily oral supplementation with pasteurized Akkermansia muciniphila could improve several metabolic markers. Over three months, participants taking the pasteurized bacteria showed significant increases in insulin sensitivity and reductions in both insulin levels and total plasma cholesterol compared to a placebo group.
The study investigated whether introducing this specific bacterium, which is typically less abundant in individuals with obesity or type 2 diabetes, could influence metabolic health. The researchers observed that the intervention also reduced certain blood markers for inflammation and liver dysfunction.
This was a small, single-center, randomized, double-blind, placebo-controlled trial involving 32 completed participants. While some trends toward weight and fat mass reduction were noted, these changes did not reach statistical significance.
Why it matters: Supplementing with pasteurized Akkermansia muciniphila may offer a way to improve key metabolic parameters in individuals with obesity.
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Sources
- Summary by Intellect · source: Research: Depommier et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature medicine.
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