How triple-stranded DNA works
In short: Triple-stranded DNA, or H-DNA, forms a triple helix when three oligonucleotides wind around each other.
1. Triple-stranded DNA is a structure in which three oligonucleotides wind around each other and form a triple helix. 2. The third strand binds to a B-form DNA double helix by forming Hoogsteen base pairs or reversed Hoogsteen hydrogen bonds. 3. The thymine hydrogen bonds with the adenosine of the original double-stranded DNA to create a T-A*T base-triplet. 4. Triple-stranded DNA regions can be generated through the association of Triplex Forming Oligonucleotides and Peptide Nucleic Acids.
Sources: Wikipedia, “Triple-stranded DNA (Wikipedia)” (CC BY-SA 4.0). Illustrative, not to scale.
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