The Mole-Rat Puzzle: How Long Can Heterocephalus glaber Live?
In short: Captive naked mole-rats (Heterocephalus glaber) have lived to 40 without a rising risk of death with age, and researchers are still testing hypotheses for why.
A 1:29 short film in the series “Nature: How Long Can It Live?”, narrated by intellect_voice_01.
Sources used in this film: Nature (via PubMed Central, US National Library of Medicine / NCBI); author manuscript of Kim et al., Nature 2011, 479(7372):223–227, “Genome sequencing reveals insights into physiology and longevity of the naked mole rat”; Nature (Springer Nature), “Genome sequencing reveals insights into physiology and longevity of the naked mole rat - Nature”; Smithsonian's National Zoo & Conservation Biology Institute, “Naked mole-rat”; PubMed Central (US National Library of Medicine, NIH); article published in GeroScience (Springer), DOI 10.1007/s11357-024-01201-4, “Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age”; GeroScience (Springer Nature), “Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age - GeroScience”; PMC (PubMed Central), U.S. National Library of Medicine / NCBI; article by researchers including Rochelle Buffenstein (Calico Life Sciences LLC), “The Naked Mole-Rat: An Unusual Organism with an Unexpected Latent Potential for Increased Intelligence?”; Cambridge University Press (Cambridge Core), Journal of Zoology, “Extraordinary life spans of naked mole-rats (Heterocephalus glaber) | Journal of Zoology | Cambridge Core”; PubMed Central (US National Library of Medicine, NCBI); article published in the journal Aging (Albany NY), “The metabolomic signature of extreme longevity: naked mole rats versus mice”; Zoological Research (journal); review article by authors at Tongji University School of Life Sciences and Technology, “Unlocking the secrets of naked mole-rat longevity”; PubMed Central (US National Library of Medicine), hosting a journal commentary on Tian et al. 2013 (Nature), “Cancer resistance, high molecular weight hyaluronic acid, and longevity”; University of Rochester Medical Center (URMC Newsroom), “Biologists Identify Chemical Behind Cancer Resistance in Naked Mole Rats”; Journal of Muscle Research and Cell Motility (Springer), “Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat - Journal of Muscle Research and Cell Motility”.
Sources used in this film
- Nature (via PubMed Central, US National Library of Medicine / NCBI); author manuscript of Kim et al., Nature 2011, 479(7372):223–227 — Genome sequencing reveals insights into physiology and longevity of the naked mole rat · View →
- Nature (Springer Nature) — Genome sequencing reveals insights into physiology and longevity of the naked mole rat - Nature · View →
- Smithsonian's National Zoo & Conservation Biology Institute — Naked mole-rat · View →
- PubMed Central (US National Library of Medicine, NIH); article published in GeroScience (Springer), DOI 10.1007/s11357-024-01201-4 — Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age · View →
- GeroScience (Springer Nature) — Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age - GeroScience · View →
- PMC (PubMed Central), U.S. National Library of Medicine / NCBI; article by researchers including Rochelle Buffenstein (Calico Life Sciences LLC) — The Naked Mole-Rat: An Unusual Organism with an Unexpected Latent Potential for Increased Intelligence? · View →
- Cambridge University Press (Cambridge Core), Journal of Zoology — Extraordinary life spans of naked mole-rats (Heterocephalus glaber) | Journal of Zoology | Cambridge Core · View →
- PubMed Central (US National Library of Medicine, NCBI); article published in the journal Aging (Albany NY) — The metabolomic signature of extreme longevity: naked mole rats versus mice · View →
- Zoological Research (journal); review article by authors at Tongji University School of Life Sciences and Technology — Unlocking the secrets of naked mole-rat longevity · View →
- PubMed Central (US National Library of Medicine), hosting a journal commentary on Tian et al. 2013 (Nature) — Cancer resistance, high molecular weight hyaluronic acid, and longevity · View →
- University of Rochester Medical Center (URMC Newsroom) — Biologists Identify Chemical Behind Cancer Resistance in Naked Mole Rats · View →
- Journal of Muscle Research and Cell Motility (Springer) — Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat - Journal of Muscle Research and Cell Motility · View →
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Sources
- Summary by Intellect · source: Nature (via PubMed Central, US National Library of Medicine / NCBI); author manuscript of Kim et al., Nature 2011, 479(7: Genome sequencing reveals insights into physiology and longevity of the naked mole rat
- Also: Nature (Springer Nature): Genome sequencing reveals insights into physiology and longevity of the naked mole rat - Nature
- Also: Smithsonian's National Zoo & Conservation Biology Institute: Naked mole-rat
- Also: PubMed Central (US National Library of Medicine, NIH); article published in GeroScience (Springer), DOI 10.1007/s11357-0: Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age
- Also: GeroScience (Springer Nature): Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age - GeroScience
- Also: PMC (PubMed Central), U.S. National Library of Medicine / NCBI; article by researchers including Rochelle Buffenstein (C: The Naked Mole-Rat: An Unusual Organism with an Unexpected Latent Potential for Increased Intelligence?
- Also: Cambridge University Press (Cambridge Core), Journal of Zoology: Extraordinary life spans of naked mole-rats (Heterocephalus glaber) | Journal of Zoology | Cambridge Core
- Also: PubMed Central (US National Library of Medicine, NCBI); article published in the journal Aging (Albany NY): The metabolomic signature of extreme longevity: naked mole rats versus mice
- Also: Zoological Research (journal); review article by authors at Tongji University School of Life Sciences and Technology: Unlocking the secrets of naked mole-rat longevity
- Also: PubMed Central (US National Library of Medicine), hosting a journal commentary on Tian et al. 2013 (Nature): Cancer resistance, high molecular weight hyaluronic acid, and longevity
- Also: University of Rochester Medical Center (URMC Newsroom): Biologists Identify Chemical Behind Cancer Resistance in Naked Mole Rats
- Also: Journal of Muscle Research and Cell Motility (Springer): Extreme Physiology Extreme Tolerance to Hypoxia, Hypercapnia, and Pain in the Naked Mole-Rat - Journal of Muscle Research and Cell Motility
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