Why human activity is the primary architect of the next global viral pandemic

How human activity drives the transmission of infectious diseases from animals | Our Broken Planet · 44:07 · Video: Natural History Museum · Watch at the source

In short: While we often view viral outbreaks as unpredictable natural disasters, science suggests we are the true drivers. By altering landscapes and encroaching on wildlife habitats, human activity creates the perfect conditions for zoonotic spillover. Understanding this relationship is essential to preventing the next global health crisis from taking hold.

The rising frequency of emerging infectious diseases—such as COVID-19, Ebola, and mpox—is increasingly viewed by researchers as a consequence of a fundamental shift in the biosphere. Human-driven environmental changes, including deforestation, agricultural expansion, and urbanization, are actively reshaping ecological systems. These disruptions often increase the susceptibility of wildlife to infection while simultaneously creating more frequent opportunities for pathogens to jump from animals to humans, a process known as zoonotic spillover.

Despite the clear link between human behavior and disease emergence, the specific impacts of these environmental changes remain complex and context-specific. While ecosystem degradation and biodiversity loss generally correlate with higher disease prevalence in wildlife, the net effects of habitat fragmentation and climate change vary significantly depending on the pathogen's life cycle and the local ecology. This heterogeneity makes it difficult to establish a universal model for predicting where the next outbreak might occur, as human-wildlife contact patterns differ drastically across global landscapes.

Current research efforts are shifting toward systematic, data-driven assessments to better understand these risks. By harmonizing georeferenced outbreak data for 32 emerging infectious diseases—ranging from mosquito-borne arboviruses to bat-borne coronaviruses—scientists are working to identify the socio-ecological factors that correlate with disease emergence. These factors include land use change and global travel, yet data remains biased toward well-resourced regions. Addressing these gaps requires a 'One Health' approach, integrating ecological surveillance with improved clinical diagnostics and social interventions to mitigate the upstream drivers of disease before they escalate into pandemics.

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